FeraMAX® Pd Therapeutic 150 is an oral iron supplement formulated with polydextrose in a stable complex. It is manufactured by a specialized process whereby the iron is coated with polydextrose (starches/sugars). This coating allows the iron to pass through the stomach relatively intact where it is absorbed through the small intestine and is then delivered to the bloodstream.

• It is a dark brown powder which, when dissolved in water forms a very dark brown solution.

• It is virtually tasteless and odorless.

• It is an organic complex and contains no free ions, also described as being non-ionic.

• Due to the polysaccharide coating (matrix) it is electrically neutral.

The patented formulation sets FeraMAX® Pd Therapeutic 150 apart from all other oral iron supplements. It does not have a generic and cannot be substituted. The unique polydextrose delivery mechanism assures a more uniform molecular structure of the iron complex, leading to a more reproducible, reliable quality.

FeraMAX® Pd Therapeutic 150 is manufactured in North America, in a US FDA and Health Canada- approved facility.

The new packaging and capsules take patient safety into consideration and help easy identification.

FeraMAX® Pd Therapeutic 150 continues to deliver the same proven efficacy, and tolerability with the convenience of once daily dosing, and can be taken with or without food.

Vegan-certified and recognized by the Society of Obstetricians and Gynecologists of Canada. Gluten, lactose, alcohol-free.

We have redesigned the packaging to make it more patient-friendly, so you can find relevant clinical information easily. FeraMAX® and dose are clearly visible on the capsule, using advanced printing technology, to help identify FeraMAX® Pd Therapeutic 150 and organize your medications easily.

FeraMAX® is now available in a new and enhanced formulation. The Pd in the new FeraMAX® logo, stands for Polydextrose. FeraMAX® Pd Therapeutic 150 is the only Polydextrose Iron Complex (PDIC) in Canada.

The ferric iron (Fe3+) is now complexed with polydextrose, which leads to a more uniform molecular structure. This is a patented formulation and makes FeraMAX® Pd Therapeutic 150 unique.

The packs and capsules have been redesigned to improve ease of use, and identification among other medications.

FeraMAX® Pd Therapeutic 150 capsules can be opened carefully over the sink, and the contents mixed into a glass of water or sprinkled over soft foods.

• Medicinal ingredient: Polydextrose-iron complex
• Non-medicinal ingredients: carrageenan, D&C Red #33, D&C Yellow #10, FD&C Blue #1, FD&C Red #40, FD&C Yellow #6, hypromellose, magnesium stearate, microcrystalline cellulose, potassium chloride, and titanium dioxide.

FeraMAX® Pd Therapeutic 150 is a unique, patented formulation using an enhanced delivery system for elemental iron. It is the only Polydextrose Iron Complex (PDIC) in Canada. There is no generic available.

FeraMAX® Pd Therapeutic 150 does not contain lactose, gluten in its formulations. These are the most common ingredients that patients are concerned about. It does contain artificial coloring agents and trace amounts of sodium.

Because FeraMAX® Pd Therapeutic 150 is taken only once a day and is rapidly absorbed, it should be possible to safely adjust the dosage schedules and thereby minimize possible interaction in the gastric system. It is generally sufficient if the doses are adjusted so that they are taken a few hours before or after other medication. Use caution when prescribing FeraMAX® Pd Therapeutic 150 with the following pharmaceuticals:

• Antacids
• Tetracyclines (e.g., doxycycline, minocycline, tetracycline)
• Quinolines (e.g., cipro, floxin, levaquin, tequin)
• Chloramphenicol
• Pancreatic enzymes
• Thyroid hormones
• Alendronate
• Cefdinir
• Etidronate

Ferrous (iron) salt supplements have a number of unwanted side effects including nausea, vomiting, epigastric pain, and constipation. Because of these adverse effects, many users stop taking their supplements, which can lead to a rapid deterioration of their health. In contrast, most users of polydextrose-iron complex (PIC) supplements report that they experience either very few or no side effects. This increases patient compliance with the supplement dosage and duration prescribed by their physician.

Many oral iron supplements should be taken on an empty stomach; however this increases the likelihood of adverse side effects. Due to its formulation and how it is absorbed, FeraMAX® Pd Therapeutic 150 can be given with or without food. It is best to take FeraMAX® Pd Therapeutic 150 at the same time each day.

FeraMAX® Pd Therapeutic 150 delivers 150 mg of elemental iron per capsule – the highest dosage of bioavailable iron in an iron supplement. One capsule per day provides all of the iron necessary for treating iron deficiency and iron deficient anemia.

Polydextrose-iron complex absorption across the cell membrane in the duodenum is mediated by the transporter DMT-1. Once inside the enterocyte, iron can exit into the bloodstream and bind with transferrin or, if the body’s need for iron is met, the iron binds to ferritin inside the enterocyte which will eventually be eliminated. The transferrin-iron complex rapidly delivers iron to bone marrow and red blood cell precursors, where it is taken up by receptor-mediated endocytosis and used to form hemoglobin.

Extra iron is stored primarily in the liver, bone marrow, and to a lesser extent in the spleen.

FeraMAX® Pd Therapeutic 150 is positively charged and soluble at pH < 4.0. This solubility at low pH may be associated with improved absorption.
X-ray diffraction analysis shows that polysaccharide-iron complexes have a ferrihydrite (β-FeOOH) structure that closely resembles the structure of ferritin, the natural intracellular protein that binds iron in duodenal cells.

The fact that the polydextrose-iron complex closely resembles endogenous carriers of iron could account for its high bioavailability and reduced side effects.

Conventional iron supplements are ferrous (iron) salts, which release iron in the stomach. This is responsible for most side effects associated with iron therapy such as nausea, vomiting, dyspepsia, constipation, diarrhea, dark stools, and bloating. Because of the side effects, patients might stop taking the iron salt. Stopping medication could lead to poor results and treatment failure.

Oral iron salt supplements contain 35 to 100 mg of elemental iron per capsule. Because of this low dose, in order to achieve treatment success, all such forms of oral iron need to be taken 2 to 3 times daily.

By contrast, FeraMAX® Pd Therapeutic 150 liberates less ionic iron in the stomach compared to iron salts as it is less affected by the acidity in the stomach. It releases its ferric iron closer to the site of absorption in the duodenum. FeraMAX® Pd Therapeutic 150 delivers an optimal dose of 150 mg of elemental iron per capsule, convenient for once-daily dosing, and helps patients stay with the treatment.

It is also Vegan Certified, and hence appropriate for all patients. Some iron supplements (with heme iron) contain animal products, and hence might be unsuitable for patients with dietary restrictions.

Yes! FeraMAX® Pd Therapeutic 150 is the only polydextrose-iron complex (PDIC) in Canada.

FeraMAX® is known for innovation in iron therapy, and as reliable partners to HCPs in the management of Iron Deficiency. First to market with a vegan-certified capsule, and first to market with a water-soluble powder.

FeraMAX® Pd Therapeutic 150 is manufactured in North America, in a US FDA and Health Canada- approved facility.